Kura Oncology, Inc. (NASDAQ:KURA) Q3 2019 Earnings Conference Call - Final Transcript

Nov 05, 2019 • 04:30 pm ET


Kura Oncology, Inc. (NASDAQ:KURA) Q3 2019 Earnings Conference Call - Final Transcript


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Ladies and gentlemen, thank you for standing by, and welcome to the Third Quarter 2019 Kura Oncology Earnings Conference Call. [Operator Instructions]

I would now like to hand the conference over to your speaker today, Pete De Spain, Vice President, Investor Relations at Kura Oncology. Please go ahead.

Pete De Spain

Thank you, Sarah. Good afternoon, and welcome to Kura Oncology's third quarter 2019 conference call. Joining me on the call from Kura are Dr. Troy Wilson, our President and Chief Executive Officer; and Dr. Marc Grasso, our Chief Financial Officer and Chief Business Officer. Dr. Antonio Gualberto, our Chief Medical Officer and Head of Development, is also with us and available to answer questions.

Before I turn the call over to Dr. Wilson, I would like to remind you that today's call will include forward-looking statements based on current expectations. Such statements represent management's judgment as of today and may involve risks and uncertainties that could cause actual results to differ materially from expected results. Please refer to Kura's filings with the SEC, which are available from the SEC or on the Kura Oncology website for information concerning risk factors that could affect the Company.

With that, I'll now turn the call over to Dr. Troy Wilson, President and CEO of Kura Oncology.

Troy Wilson

Thank you, Pete, and thank you all for joining us this afternoon. I'd like to start by introducing the two newest members of our senior leadership team, Kathleen Ford, our Chief Operating Officer; and James Basta, our Chief Legal Officer. Kathy, joined us in July, at a time when strategic prioritization and operational execution became our highest priorities, and she has made an immediate impact. She most recently served at Merck Serono, where she lead clinical and development operations towards successful drug registrations in both the U.S. and Europe. Jim, joined us just yesterday from Biogen, where he spent the past 13 years, most recently as Senior Vice President, Chief Corporation Counsel. He brings a healthy balance of strong business partnering and corporate guardianship, and we're excited to have him on Board. Both are welcome additions to our team.

Now, let me bring you up to speed on each of our programs beginning with tipifarnib in HRAS mutant solid tumors. Last week, we reported updated data from our ongoing Phase 2 trial of tipifarnib in HRAS mutant head and neck squamous cell carcinomas, at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics or the Triple Meeting in Boston. We were very pleased because the results demonstrate a compelling level of clinical activity for tipifarnib in a difficult to treat patient population. They validate our strategy to enrich for clinical activity and the data strongly support the design of our ongoing AIM-HN registration-directed trial.

However, before I discuss the significance of these results in more detail, let me quickly recap the data themselves. As of the October 17, 2019 data cut-off date, a total of 21 HNSCC patients with high HRAS mutant variant allele frequency were enrolled in the